SHREC: a short-read error correction method

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SHREC: a short-read error correction method

MOTIVATION Second-generation sequencing technologies produce a massive amount of short reads in a single experiment. However, sequencing errors can cause major problems when using this approach for de novo sequencing applications. Moreover, existing error correction methods have been designed and optimized for shotgun sequencing. Therefore, there is an urgent need for the design of fast and acc...

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Developing accurate, scalable algorithms to improve data quality is an important computational challenge associated with recent advances in high-throughput sequencing technology. In this study, a novel error-correction algorithm, called ECHO, is introduced for correcting base-call errors in short-reads, without the need of a reference genome. Unlike most previous methods, ECHO does not require ...

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ژورنال

عنوان ژورنال: Bioinformatics

سال: 2009

ISSN: 1367-4803,1460-2059

DOI: 10.1093/bioinformatics/btp379